Fig. 11 | Scientific Reports

Fig. 11

From: PDT-regulated immune gene prognostic model reveals tumor microenvironment in colorectal cancer liver metastases

Fig. 11

PDT inhibited the proliferation and migration of colorectal cancer cells, increase the expression of ICOS and decrease HSPA1A and SLC11A1 expression. (A,B) The proliferation capacity was measured by EdU assay in HCT15 and HCT116 cells with PDT. (C–E) Wound healing was used to detect the ability of migration of HCT15 and HCT116 cells after PDT. (F) The mice were randomly divided into control group and PDT group, with 4 mice in each group. Intervention methods are described in Materials and methods. After 14 days, mice were sacrificed and tumors were shown. (G,H) The weight and tumor volume of the mice were recorded every 2 days. (I) The expression of HSPA1A, ICOS and SLC11A1 was analyzed by IHC staining (Bar, 50 μm). *p < 0.05, ***p < 0.001, ****P < 0.0001.

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