Fig. 7
From: A specific role for endothelial EPLIN-isoform-regulated actin dynamics in neutrophil transmigration
Scheme, illustrating the proposed series of events during leukocyte transmigration through activated endothelium in an EPLIN-dependent manner. (1) After the neutrophils firmly adhere to the activated endothelium, branched actin filaments develop under the control of EPLIN-α, forming docking structures. At the same time, the neutrophils begin to penetrate through a gap that is free of VE- cadherin. (2) During transmigration of the leukocyte EPLIN-β stabilizes actin bundles sourrounding the gaps (blue circles) to most likely seal the gaps protecting the endothelium from uncontrolled leakage, and persist until leukocyte transmigration is completed. (3) It appears that VL/JAIL are already formed in the terminal phase of leukocyte transmigration, triggered by the Arp2/3 complex and controlled by EPLIN-α. (4) After leukocyte transmigration is complete, VL/JAIL form with increasing frequency, a process that ultimately closes the transmigration gap.
