Fig. 1 | Scientific Reports

Fig. 1

From: Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder

Fig. 1

Distribution and firing patterns of DRNmPFC 5-HT neurons in the Raphe. (A) Schematic of injection of retrograde pAAV-CAG-tdTomato in the mPFC. (B) Rostro-caudal distribution of tdTomato labeled DRNmPFC neurons for (red), immunostaining for Tph2 (green). Note that most of the DRNmPFC 5-HT neurons are located in ventral DRN (vDRN). (C) High magnification images of DRN neurons expressing Tph2 (green) and tdTomato (RED). (D) Percentage of Tph2 and tdTomato positive DRN neurons. (E) The distinct firing patterns of DRNmPFC 5-HT neurons elicited by suprathreshold depolarizing current pulses.

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