Fig. 6
From: Attenuated PINK1 autophosphorylation play neuroprotective and anti-seizure roles in neonatal hypoxia

Inhibition of OMA1 expression further increased the levels of phosphorylated PINK1/Parkin/Ub during hypoxia-induced seizures. (A-J) Changed levels of OMA1, PINK1/P-PINK1 and Parkin/P-Parkin in the cortex and hippocampus caused by OMA1 intervention were detected by western blotting (n = 4/group). (K,L) P-Ub (red) immunofluorescence intensity in the EC and DG (3 day; n = 4/group). DAPI, blue. Bar = 50 μm. Mean ± SEM. Compared with controls, *P < 0.05, **P < 0.01, and ***P < 0.001 (one-way ANOVA). C cortex, DG dentate gyrus, EC entorhinal cortex, H hippocampus, Hy Hypoxia, OMA1 overlapping with the m-AAA protease 1 homolog, P-Parkin phosphorylated Parkin, P-PINK1 phosphorylated PTEN-induced kinase 1, P-Ub phosphorylated ubiquitin.