Fig. 4
From: Engineered models to parse apart the metastatic cascade
Precision oncology approaches to cancer metastasis studies illustrates the flow of samples and information gained from the different types of models used to study the metastatic cascade. Patient-derived tissue samples can be used directly in in vivo models or for characterization in in vitro platforms. In vitro models incorporating primary samples can be used to inform drug-development or characterize subpopulations of cells to be used in in vivo models. In vivo tissues can be extracted for characterization in in vitro platforms to better inform future therapeutics for human patients
