Fig. 4: Weight maps of tiles when predicting the point mutation status of RB1 and cell cycle pathway activity from mRNA expression data in breast cancer.

a Tumor tiles after data processing. b Weight map of tumor tiles in RB1 point mutation prediction. Brighter green tiles have larger weights. c Weight map of the cell cycle pathway activity prediction. d, e Top 20 weighted tiles for the RB1 point mutation prediction and cell cycle pathway prediction, respectively. We marked four tiles that appear in both tasks. These tissues contain poorly differentiated breast carcinoma with necrosis or hemorrhage from a pathologist’s perspective.