Fig. 1: Outline of workflow and proteomic landscape of patients from discovery cohort.

a Study design and flow chart. b Heatmap of proteins significantly associated with recurrence in CRC. c GSEA (H: Reactome) analysis of stage II/III CRC patients revealed the pathways associated with relapse (n = 30) or non-relapse (n = 30). LC-MS/MS Liquid chromatography tandem mass spectrometry, CRC Colorectal cancer, SY6H Sun Yat-sen University, the Sixth affiliated Hospital.