Fig. 2: CircCCDC7(15,16,17,18,19) was downregulated in tumor samples and associated with good prognosis. | npj Precision Oncology

Fig. 2: CircCCDC7(15,16,17,18,19) was downregulated in tumor samples and associated with good prognosis.

From: A protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT3

Fig. 2

a, b Expression of circCCDC7(15,16,17,18,19) (a) and linear CCDC7 (b) in 134 pairs of PCa and normal margin samples from CPGEA by using Mann–Whitney test. c The absence of correlation between circCCDC7(15,16,17,18,19) and linear CCDC7 in CPGEA. d, e Quantitative PCR measuring the expression of circCCDC7(15,16,17,18,19) (d) and linear CCDC7 (e) in 23 pairs of clinical samples from Sun Yat-sen Memorial Hospital. The primers for linear CCDC7 were designed to amplify the junction sequences between exon40 and exon41 to avoid all reported circular transcripts. Mann-Whitney test was used to explore the group difference. f The absence of correlation between circCCDC7(15,16,17,18,19) and linear CCDC7 in Sun Yat-sen Memorial Hospital clinical samples. g Expression of circCCDC7(15,16,17,18,19) in different Gleason scored samples from CPGEA. Mann–Whitney test was used to explore the group difference. h, i BCR-free survival analysis of circCCDC7(15,16,17,18,19) (h) and linear CCDC7 (i) in CPGEA by using normalized read counts. *p < 0.05. ****p < 0.0001.

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