Fig. 4: Interaction between lab and panel product, and SHAP values of key factors. | npj Precision Oncology

Fig. 4: Interaction between lab and panel product, and SHAP values of key factors.

From: Enhancing the quality of panel-based tumor mutation burden assessment: a comprehensive study of real-world and in-silico outcomes

Fig. 4

a The eTMB results of different panel methods on the five undiluted gDNA samples. Methods only used by one lab are gathered as “other”. The reference wesTMB values of these samples are shown as horizontal dotted lines. b The stacked barplot right side from AVOVA shows the relative contributions of listed factors to the eTMB results. c SHAP values of technical factors on the continuous accuracy of panel-based TMB methods. d SHAP values of technical factors on the discrete accuracy of panel-based TMB methods. Technical factors are ranked by the relative importance from top (most important) to bottom.

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