Fig. 5: Detailed influence of panel size and mutation detection accuracy. | npj Precision Oncology

Fig. 5: Detailed influence of panel size and mutation detection accuracy.

From: Enhancing the quality of panel-based tumor mutation burden assessment: a comprehensive study of real-world and in-silico outcomes

Fig. 5

a Impact of panel size and gene count on RMSLE and discrete accuracy of panel-based TMB assessment. The fitting curves represent the synthetic panels. The red dots represent the real panels. Confidence intervals of 95% are indicated by the light blue shadow. Critical panel size and gene count values (inflection points) and 95% theoretically best accuracy are shown as vertical lines. b Accuracy of panels on cell line-derived gDNA samples. c Distribution of RMSLE and the reciprocal gap between recall and precision on gDNA samples. d Impact of precision and recall value pairs on RMSLE and discrete accuracy of panel-based TMB assessment.

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