Fig. 5: Rab27A promotes exosome-derived IFNα to upregulate TYK2 phosphorylation. | npj Precision Oncology

Fig. 5: Rab27A promotes exosome-derived IFNα to upregulate TYK2 phosphorylation.

From: Targeting TYK2 alleviates Rab27A-induced malignant progression of non-small cell lung cancer via disrupting IFNα-TYK2-STAT-HSPA5 axis

Fig. 5

a The IFNα concentration in the cell supernatant from A549 and H1299 cells with the indicated shRNAs. b The IFNα concentration in the cell supernatant from A549 and H1299 cells with the indicated lentiviral vectors. c Exosome secretion inhibitor DMA treatment significantly reduced the IFNα concentration in the cell supernatant of Rab27A-overexpressing A549 and H1299 cells. d The upregulation effect of TYK2 phosphorylation mediated by Rab27A-overexpression could be reversed by DMA in A549 and H1299 cells. e IFNA2-knockdown reversed the upregulation effect of IFNα concentration in the cell supernatant mediated by Rab27A-overexpression in A549 and H1299 cells. f The upregulation effect of TYK2 phosphorylation mediated by Rab27A-overexpression could be reversed by IFNA2-knockdown in A549 and H1299 cells.

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