Table 1 Cox regression analysis of UAB36 with established gene signatures and clinical risk factors for overall survival in the tamoxifen treated METABRIC ER+/HER2− cohort (n = 895)

From: Development of a polygenic score predicting drug resistance and patient outcome in breast cancer

 

Univariate model

Multivariate model

Variables

HR

P

HR

P

UAB36 (high vs. low)a

1.33

1.11E−03

1.28

2.34E−02

ENDORSE (high vs. low)a

1.26

7.93E−03

1.02

9.22E−01

PAM50 (high vs. low)a

1.39

1.63E−04

1.05

7.58E−01

AGE (continuous)

1.06

<2E−16

1.06

<2E−16

TUMOR STAGE

1.69

8.40E−09

1.39

7.66E−04

TUMOR GRADE

1.18

1.63E−02

1.12

2.09E−01

  1. aIn both univariate and multivariate Cox regression analysis, the gene set median drug score was used as a cutoff to divide patients into high and low score groups.
  2. P-value in bold typeface indicates statistical significance (P < 0.05).
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