Table 2 Treatment toxicities during every treatment period of venetoclax
Toxicities, n(%) | Cycles (n = 45) | |||||
|---|---|---|---|---|---|---|
None | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | |
Hematology | ||||||
 Leukopenia | 0 (0.0) | 2 (4.4) | 2 (4.4) | 12 (26.7) | 29 (64.4) | - |
 Neutropenia | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 45 (100.0) | - |
 Febrile neutropenia | 1 (2.2) | - | - | 44 (97.8) | 0 (0.0) | 0 (0.0) |
 Anemia | 0 (0.0) | 0 (0.0) | 3 (6.7) | 42 (93.3) | 0 (0.0) | 0 (0.0) |
 Thrombocytopenia | 1 (2.2) | 0 (0.0) | 3 (6.7) | 12 (26.7) | 29 (64.4) | - |
Respiratory | ||||||
 Pneumonia | 35 (77.8) | 2 (4.4) | 5 (11.1) | 1 (2.2) | 2 (4.4) | 0 (0.0) |
 Pleural effusion | 43 (95.6) | 2 (4.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Pulmonary atelectasis | 45 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Cardiology | ||||||
 Reduced ejection fraction | 43 (95.6) | - | 1 (2.2) | 1 (2.2) | 0 (0.0) | - |
 Sinus bradycardia | 44 (97.8) | 1 (2.2) | 0 (0.0) | 0 (0.0) | - | - |
 Sinus tachycardia | 42 (93.3) | 3 (6.7) | 0 (0.0) | 0 (0.0) | - | - |
 Abnormal T-waves on ECG | 43 (95.6) | 2 (4.4) | 0 (0.0) | - | - | - |
 hypotension | 45 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 hypertension | 44 (97.8) | 1 (2.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Gastroenterology | ||||||
 Nausea | 40 (88.9) | 5 (11.1) | 0 (0.0) | 0 (0.0) | - | - |
 Vomiting | 38 (84.4) | 5 (11.1) | 2 (4.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Diarrhea | 40 (88.9) | 5 (11.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Constipation | 44 (97.8) | 1 (2.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Increased AST | 37 (82.2) | 3 (6.7) | 5 (11.1) | 0 (0.0) | 0 (0.0) | - |
 Increased ALT | 37 (82.2) | 4 (8.9) | 4 (8.9) | 0 (0.0) | 0 (0.0) | - |
 Increased total bilirubin | 44 (97.8) | 0 (0.0) | 0 (0.0) | 1 (2.2) | 0 (0.0) | - |
 Hepatic failure | 45 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Lipase | 42 (93.3) | 0 (0.0) | 0 (0.0) | 2 (4.4) | 1 (2.2) | - |
 Amylase | 44 (97.8) | 0 (0.0) | 0 (0.0) | 1 (2.2) | 0 (0.0) | - |
 Pancreatitis | 42 (93.3) | - | 0 (0.0) | 3 (6.7) | 0 (0.0) | 0 (0.0) |
Nephrology | ||||||
 Renal damage | 42 (93.3) | - | - | 3 (6.7) | 0 (0.0) | 0 (0.0) |
 Increased creatinine | 40 (88.9) | 4 (8.9) | 1 (2.2) | 0 (0.0) | 0 (0.0) | - |
Metabolism and nutrition | ||||||
 Tumor lysis syndrome | 34 (75.6) | - | - | 11 (24.4) | 0 (0.0) | 0 (0.0) |
 Hypernatremia | 45 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Hyponatremia | 45 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Hyperkalemia | 45 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Hypokalemia | 41 (91.1) | 1 (2.2) | 3 (6.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Hypercalcemia | 45 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Hypocalcemia | 41 (91.1) | 3 (6.7) | 1 (2.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Hyperglycemia | 37 (82.2) | 7 (15.6) | 0 (0.0) | 1 (2.2) | 0 (0.0) | 0 (0.0) |
Skin/Mucosa | ||||||
 Oral mucositis | 29 (64.4) | 7 (15.6) | 9 (20.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Anal mucositis | 35 (77.8) | 5 (11.1) | 5 (11.1) | 0 (0.0) | - | - |
 Papule | 43 (95.6) | 1 (2.2) | 0 (0.0) | 1 (2.2) | - | - |
Others | ||||||
 Infections | 1 (2.2) | - | 0 (0.0) | 42 (93.3) | 2 (4.4) | 0 (0.0) |
 Septicemia | 42 (93.3) | - | - | 3 (6.7) | 0 (0.0) | 0 (0.0) |
 Pyohemia | 44 (97.8) | - | - | 1 (2.2) | 0 (0.0) | 0 (0.0) |
 Multiorgan failure | 43 (95.6) | - | - | 1 (2.2) | 1 (2.2) | 0 (0.0) |
 DIC | 37 (82.8) | - | 3 (6.7) | 4 (8.9) | 1 (2.2) | 0 (0.0) |
 Allergic reaction | 44 (97.8) | - | - | 1 (2.2) | 0 (0.0) | 0 (0.0) |
