Fig. 2: OSGIN1 confers sensitivity to ferroptosis.
From: A targetable OSGIN1 − AMPK − SLC2A3 axis controls the vulnerability of ovarian cancer to ferroptosis

a Correlation between OSGIN1 expression and erastin sensitivity, based on the ovarian cancer cell lines (n = 26) from CTRP. Dose responses are normalized area under curve values. The linear relationship was determined by a two-tailed Pearson correlation analysis. b Comparison of the levels of MDA and iron and the GSH/GSSG ratio between ovarian cancer and normal ovarian tissues (n = 7). c SKOV3 and OVCAR3 cells were treated with DMSO (control) or erastin (10 μM) alone or in combination with ferrostatin-1 (fer-1, 10 μM). Levels of intracellular reactive oxygen species after the indicated treatments. The MDA/iron ratio and GSH/GSSG ratio after the indicated treatments. d Expression of OSGIN1 mRNA and protein in ovarian cancer cells after treatment with 10 μM erastin for 24 h. All results are representative of at least three independent experiments. Statistical significance in b was determined by a two-tailed unpaired t-test.The p values in c, d were determined by two-way ANOVA with multiple comparisons, Error bars are s.e.m. *p < 0.05; **p < 0.01 and ***p < 0.001.