Fig. 4: Pazopanib + BETi is the most frequently occurring drug pair demonstrating the strongest combinatorial efficacy across all 45 primary STS patient samples. | npj Precision Oncology

Fig. 4: Pazopanib + BETi is the most frequently occurring drug pair demonstrating the strongest combinatorial efficacy across all 45 primary STS patient samples.

From: Functional combinatorial precision medicine for predicting and optimizing soft tissue sarcoma treatments

Fig. 4

a Frequency at which individual drugs and combinations appear within the top-10 unique two-drug combinations were plotted in an upset plot across all PDCs (n = 45). “Frequency of combination” refers to the number of times a drug pairing appeared within the top ten two-drug combinations across all PDCs. “Frequency of single drug” refers to the total number of times each drug has appeared within any of the top ten ranked combination. b Scatter plots showing correlation between one-drug and two-drug NCVs. Pearson correlation coefficient (r), p-, and n-values shown represent correlation analysis for the overall cohort. c Summary of mean NCV for top-ranked drug combinations against standard of care ifosfamide and doxorubicin. All statistical analyses were performed using two-tailed Student’s t test; *, P < 0.05; ****, P < 0.0001 compared to ifosfamide + doxorubicin.

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