Fig. 6: Inter- and intra-tumor analysis of CAV1 gene and protein expression in HPV-negative and HPV-positive HNSCC. | npj Precision Oncology

Fig. 6: Inter- and intra-tumor analysis of CAV1 gene and protein expression in HPV-negative and HPV-positive HNSCC.

From: Multi-omics analysis to uncover the molecular basis of tumor budding in head and neck squamous cell carcinoma

Fig. 6

a Increased mRNA expression in budding compared with non-budding HPV-negative tumors (TCGA-HNSC RNA-Seq data). b Same as (a), but for HPV-positive tumors. c Increased protein expression in budding compared with non-budding HPV-negative tumors (TCGA-HNSC RPPA data). d Same as (c), but for HPV-positive tumors. e Stepwise increasing protein expression from the bulk of non-budding tumors to the bulk of budding tumors to the buds of budding tumors in HPV-negative HNSCC (TUM-IHC cohort). f Same as (e), but for HPV-positive HNSCC.

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