Fig. 5: Pro-survival networks decreased in patients with Act and Inf phenotypes (GSE159067 dataset).
From: The responses of HNSCC patients to immunotherapy are shown by two novel co-expression patterns
A, B 2D plot depicting the amplitudes (λ) of the Act and Inf phenotypes in all examined patients and the selected co-expressed transcripts in the Act phenotype and Inf phenotype, respectively, are shown. The amplitudes’ signs indicate a spatial separation (Methods). Negative amplitudes are associated with induced Act and Inf phenotypes. The full list of additional transcripts can be found in Supplementary Data 3. C The transcripts identified in the Act and Inf phenotypes were used to perform the single-sample gene set enrichment analysis (ssGSEA, “Methods”). Among patients with both Inf+/Act+ or Inf−/Act− four biological categories (e.g., angiogenesis, EMT, hypoxia, and IL6/JAL/STAT3 signaling) enrichment scores are displayed (T-test, P value *<0.05, **<0.01, ****<0.0001).
