Table 2 Association results for known PFAS exposed patients (Horsham-Warminster-Warrington) and diseases known to be associated with PFAS.
Related organ | Disease | Effect from Lit. | Ref. | Disease in EHR | Odds Ratio from EHR (95% CI; P-value) |
|---|---|---|---|---|---|
Liver | High cholesterol | Odds ratio 1.38 | Pure hypercholesterolemia | 1.59 (CI = 1.093, 2.237; p = 0.013) | |
Kidney | Elevated uric acid | Odds ratio 1.00–1.47 | Laboratory measure not in our dataset | ||
Never assessed directly in literature | Proteinuria, unspecified | 6.67 (CI = 1.351, 20.070; p = 0.011) | |||
Never assessed directly in literature | Complications of transplanted kidney | 3.11 (CI = 1.130, 6.851; p = 0.015) | |||
Kidney cancer | Hazard ratio for increasing quartiles were 1.0, 1.23, 1.48 and 1.58 | ||||
Thyroid | Thyroid disease | Odds ratio 1.64–1.86 | Malignant neoplasm of the thyroid gland | 3.23 (CI = 1.651, 5.706; p < 0.001) | |
Primary hyperparathyroidism | 3.93 (CI = 1.061, 10.250; p = 0.021) | ||||
Unspecified acquired hypothyroidism | 1.53 (CI = 1.177, 1.967; p = 0.002) | ||||
Ulcerative colitis | Adj. rate ratio 1.76–2.86 | Toxic gastroenteritis and colitis | 4.41 (CI = 1.188, 11.502; p = 0.014) | ||
Regional enteritis of unspecified site | 3.11 (CI = 1.411, 5.985; p = 0.003) |
