Extended Data Fig. 9: Transcription factor analysis for Western Diet-fed GF mice.
From: Microbial metabolite delta-valerobetaine is a diet-dependent obesogen
Transcription factor enrichment analysis shows that Ppara target genes are upregulated by a) microbiome acquisition and VB treatment in control diet fed GF mice. Ppara target genes are downregulated by VB treatment in Western diet (WD) fed GF mice. b) VB treatment in WD fed mice downregulates genes linked to Ppara which function in mitochondria and lipid processing pathways (p-value < 0.005, FC < 0.8).
