Extended Data Fig. 4: Fasting blood glucose, body weights, serum suPAR and triglycerides in mice made diabetic by STZ, or genetic predisposition (Akita), or high fat diet (HFD).

a) Bar graph shows the fasting blood glucose in male B6-Xor^WT, B6-Xor^em1 and D2-WT mice (n = 6/group) and female B6-Xor^WT (n = 4), B6-Xor^em1 (n = 5) and D2-WT mice (n = 6) at 12 weeks of diabetes. b) Serum suPAR levels in diabetic B6-Xor^WT, B6-Xor^em1 (n = 5/group) and D2-WT mice (n = 4). c) Fasting blood glucose and d) body weight (g) of Akita B6 (n = 4) and Akita B6-Xor^em1 mice (n = 5) at 12 weeks of diabetes. e) Shows the fasting blood glucose, f) the body weight, g) triglycerides (mg/dL) and h) serum suPAR levels in B6-Xor^WT and B6-Xor^em1 after 16 weeks of high fat diet (HFD, n = 5 mice/group). All data are presented as mean values ±SEM. In a) a two-way analysis of variance and Tukey’s multiple comparisons test was performed (*P < 0.05). In b-h) unpaired two-tailed Student’s t-tests was performed and showed no statistical significance between the groups.