Extended Data Fig. 1: Activation of Myh6-MerCreMer with low doses of tamoxifen has no deleterious effects on cardiac function. | Nature Metabolism

Extended Data Fig. 1: Activation of Myh6-MerCreMer with low doses of tamoxifen has no deleterious effects on cardiac function.

From: CRAT links cholesterol metabolism to innate immune responses in the heart

Extended Data Fig. 1

Adult Myh6-MerCreMer− or Myh6-MerCreMer + male and female mice were injected with tamoxifen for 4 consecutive days at a dose of 20 mg/kg/day. a, b, Echocardiographic analyses were performed to estimate cardiac contractile function after 2 months. c-f, RT-PCR analysis of the expression of the hypertrophic marker genes and the pro-fibrotic genes in the hearts. No significant changes were observed between these two groups. n = 5 mice per group. Data are shown as the mean ± SEM. Analysis was unpaired two-tailed Student’s t-test (a-f). NS, not significant.

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