Extended Data Fig. 2: Cardiomyocyte-specific deletion of CRAT increases acetyl-CoA level in the hearts.
From: CRAT links cholesterol metabolism to innate immune responses in the heart
a, Western-blots showed that CRAT was specifically depleted in CRAT-mKO male and female hearts but not in lungs or gastrocnemius muscles. b, CRAT activity was dramatically decreased in CRAT-mKO male and female hearts. c, Acetyl-CoA level was significantly increased in CRAT-mKO male and female hearts. n = 4 (a), 9 (b, WT), 7 (b, mKO), 12 (c, WT), 7 (c, mKO) mice per group. Data are shown as the mean ± SEM. Analysis was unpaired two-tailed Student’s t-test (a-c).
