Fig. 4: Ranolazine diminishes the neural crest stem cell state. | Nature Metabolism

Fig. 4: Ranolazine diminishes the neural crest stem cell state.

From: Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy

Fig. 4

a, Uniform manifold approximation and projection (UMAP) visualization of 10,133 cells coloured by treatment groups and replicate. b, Melanoma cell states according to Rambow et al.6 enriched (hypergeometric tests) in the top gene markers of each treatment group. The dashed line indicates P = 0.05. c, NCSC signature scores represented by violin plots. d, UMAP plot coloured by the expression of the NCSC state. e, Discrete expression of the NCSC state based on the 90th percentile of signature scores across the whole dataset. f, UMAP plot coloured by the expression of NGFR. g, GOBP terms enriched (hypergeometric tests) in the subset of genes (top 200) most highly correlated to the NCSC signature score. A UMAP plot of the VR compartment coloured for the NCSC signature is indicated. The dashed line indicates P = 0.05.

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