Extended Data Fig. 1: Elevated FAO regulator expression during BRAFi-acquired resistance development.

a, Dose response curve for vemurafenib (BRAFi) in A375 cells and A375VR cells. b, qPCR analysis of the indicated genes in A375 cells treated with BRAFi. Shown is the expression at week 1, 2 and 3 after the establishment of persister #7.0. Data are presented as the mean ± s.d. based on n = 3 sample replicates analysed by two-tailed unpaired t-test. *P < 0.05; **P < 0.01; ***P < 0.001.