Extended Data Fig. 7: Pyy deficiency is not associated with hyperphagia.
From: Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism
(a) Targeting strategy for generation of a Pyy knockout allele. (b) Representative genotyping gels of novel Pyy knockout allele. (c) PYY plasma levels after overnight fast from serum of 8-week-old genotype-segregated male mice of either genotype on regular chow mice (n = 10 Pyy+/+ or 11 Pyy-/- mice). (d) Weight curve for Pyy-/- or Pyy+/+ HFD-fed and regular chow-fed male mice and (e) average daily food intake at 8 weeks of age (n = 8 mice). Mean values are represented by bars and individual values by jitter plots. Error bars are ± s.e.m. Two-tailed unpaired t-test used for all pairwise comparisons.
