Extended Data Fig. 4: Microglial mitochondrial complex III function is not required for control of Aβ plaque deposition or progression of memory deficits in AD. | Nature Metabolism

Extended Data Fig. 4: Microglial mitochondrial complex III function is not required for control of Aβ plaque deposition or progression of memory deficits in AD.

From: Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation

Extended Data Fig. 4

Average speed of mice in Morris water maze in (a) 4 month, (b) 9 month, and (c) 1 year hidden trials. 4 month Morris water maze (d) 4 months: RISP-cHET CTRL n = 6 (M = 3, F = 3), RISP-cKO CTRL n = 6 (M = 4, F = 2), RISP-cHET 5xFAD n = 10 (M = 3, F = 7), RISP-cKO 5xFAD n = 7 (M = 6, F = 1) (e) 9 months: RISP-cHET CTRL n = 17 (M = 7, F = 10), RISP-cKO CTRL n = 16 (M = 6, F = 10), RISP-cHET 5xFAD n = 23 (M = 10 F = 13), RISP-cKO 5xFAD n = 21 (M = 14, F = 7)). (f) 1 year: RISP-cHET n = 13 (M = 5, F = 8), RISP-cKO n = 10 (M = 3, F = 7), RISP-cHET 5x n = 10 (M = 6, F = 4), RISP-cKO 5xFAD n = 11 (M = 7, F = 4). In a-f we used an RM two-way ANOVA with the Giesser-Greenhouse correction and an uncorrected Fisher’s LSD, with individual variances computed for each comparison. Data represent mean ± s.e.m. black asterisks indicate significant differences between RISP-cHET and RISP-cHET 5xFAD mice, blue asterisks indicate significant differences between RISP-cKO and RISP-cKO 5xFAD mice, crosses indicate significant differents between RISP-cHET 5xFAD and RISP-cKO 5xFAD mice, hashtags indicate significants differences between RISP-cHET and RISP-cKO mice. When compared with specific group indicated *p < 0.05, **p < 0.01, ***p < 0.001.

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