Extended Data Fig. 6: Time-course expression analysis for striatal GSTO2 and TH. | Nature Metabolism

Extended Data Fig. 6: Time-course expression analysis for striatal GSTO2 and TH.

From: Impaired striatal glutathione–ascorbate metabolism induces transient dopamine increase and motor dysfunction

Extended Data Fig. 6

a–c) Expression analysis of GSTO2 and TH by WB from striatal tissue homogenates of mutants and controls at different stages, with respective quantification in fold change of control. TrkbPenk-KO vs TrkbPenk-WT a) at 5 M (GSTO2, p = 0.076; TH, p = 0.12), n = 3 each cohort/genotype, (1 male and 2 females per cohort/genotype); b) at 7 M (GSTO2, p = 0.58; TH, p = 0.23), n = 3 each cohort/genotype, all females; c) at 9 M (GSTO2, p = 0.85; TH, p = 0.50), n = 3 each cohort/genotype, all females). GAPDH loading control; values are means ± SEM; p statistic from unpaired, two-tailed, Student’s t-test. Related to Fig. 5.

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