Extended Data Fig. 5: Additional analysis of TMEM162 and rs541169.
(a) Stacked bar plots showing the proportions of the given types of irAEs according to the rs541169 genotype (Carrier, N = 158 patients, Non-carrier, N = 435 patients). Non-carriers are homozygous wildtype (C/C) whereas carriers are heterozygous or homozygous mutant (C/T or T/T). Nominal P values below the irAE labels were calculated by the two-sided Chi-squared test. MSK, Musculoskeletal; GI, Gastrointestinal; Multiple, Multiple (any grade); Multiple2, Multiple (grade ≥ 2). (b) Gene expression of TMEM162 broken down by tissue types according to the Illumina Human BodyMap data set (Genome Res. 22:1760-1774) (N = 48 samples). The data was obtained from https://www.ebi.ac.uk/gxa/experiments/E-MTAB-513/Results. (c, d) Gene expression of (c) TMEM162 and (d) BTN2A1 broken down by cell types according to the Genotype-Tissue Expression Project (GTEx) data set (Science 348:648–660; Science 348:660–665) (N = 948 samples). Boxplot displays the 25th and 75th percentiles with the median represented by the center bar, and the whiskers show the farthest outliers within 1.5 times the interquartile range. The data was obtained from https://gtexportal.org/home/. Tissues of origin (x-axis) are sorted by the alphabetical order.
