Extended Data Fig. 1: irAE co-occurrence map and PCA of gene expression data. | Nature Cancer

Extended Data Fig. 1: irAE co-occurrence map and PCA of gene expression data.

From: Integrative analysis of risk factors for immune-related adverse events of checkpoint blockade therapy in cancer

Extended Data Fig. 1

(a) Connection map constructed among 9 major irAE labels based on their co-occurrence frequencies using visNetwork R package. The size of the nodes indicates the number of patients with each irAE type. The width of edges between two irAE labels indicates the number of patients with both irAE types. Any, Multiple (any grade), and Multiple (grade ≥ 2) irAE were excluded from the map. Patients with more than one irAE onset (among the 9 major labels) were used to construct the map (N = 275 patients). (b) Principal component analysis performed with the expression of protein-coding genes (N = 19,951 genes) as input. Each colored group represents (left) the institution from which the RNA sequencing data was produced or (right) the time point when the data was produced (PRE vs EDT) (N = 259 patients, PRE and EDT matched).

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