Extended Data Fig. 1
a. Comparison of the expression levels of PIK3CG and PIK3R5 across AML and healthy tissues. P-values calculated using one-way ANOVA. Error bars represent mean ± SD. b-d. Expression levels of PIK3CG and PIK3R5 in AML patients from various FAB (b) and genetic (c) subcategories, or at diagnosis versus relapse (d). Median with lower and upper hinges corresponding to the first and third quartiles. The lower and upper whiskers represent the lowest and largest value within 1.5 times the lower and upper interquartile, respectively. The points represent individual values. P-values calculated using two-sided Wilcoxon test and reported on the figure panel. e and f. Spearman correlation between AML cell differentiation state and the expression of PIK3CG and PIK3R5. Correlation between PIK3CG or PIK3R5 expression and ssGSVA score were tested using Spearman’s rank correlation. Two-sided p-values were corrected for multi-testing using the Benjamini & Hochberg method. f. The smooth area corresponds to the 95% confidence interval of the linear regression model. b-f. Data generated using the Beat AML cohort. a-d: n values displayed on the graph.
