Extended Data Fig. 4: scRNA UMAP presentation of selected biomarkers. | Nature Cancer

Extended Data Fig. 4: scRNA UMAP presentation of selected biomarkers.

From: Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses

Extended Data Fig. 4

scRNAseq was conducted on bone marrow cells from CB839 treated patients. 5 clinical responders and 3 non responders were analyzed, and 11 distinct cell populations identified based on gene expression patterns. Representative UMAP figures show enrichment of CXCL8 (A), S100A9 (B) and S100A8 (C) expression shown between responders and non-responders.

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