Extended Data Fig. 7: Expression and DNA methylation of the Trim28+/D9-light hypo-methylated signature in human patients, and their effects.
a) Heatmap of the effects on overall survival probability of expression of the indicated genes and tumor types. P-value cut-off = 0.05, by linear regression analysis. N=10013 samples. b) Heatmap of the effects on disease-free survival probability of expression of the indicated genes and tumor types. P-value cut-off = 0.05, by linear regression analysis. N=10013 samples. c) Heatmap of the effects on overall survival probability of DNA methylation at Transcription Start Sites (TSS) of the indicated genes and tumor types. P-value cut-off = 0.01, by linear regression analysis. N=10013 samples. d) Heatmap of the effects on disease-free survival probability of DNA methylation at TSS of the indicated genes and tumor types. P-value cut-off = 0.01, by linear regression analysis. N=10013 samples. e) Heatmap showing the expression profile of Trim28+/D9-light signature genes, across tumor types from the TCGA Pan-Cancer Atlas. Primary tumors are separated from the available matching normal tissues. N=10013 samples. f) Heatmap showing DNA methylation profile at TSS of all Trim28+/D9-light signature genes, across tumor types from the TCGA Pan-Cancer Atlas. Primary tumors are separated from the available matching normal tissues. N=10013 samples. In all panels, the analyses include all samples from the TCGA Pan-Cancer Atlas with available RNA-seq and DNA methylation array data (N=10013 samples). TCGA Pan-Cancer Atlas legend: LAML=Acute Myeloid Leukemia; ACC=Adrenocortical carcinoma; BLCA=Bladder Urothelial Carcinoma; LGG=Brain Lower Grade Glioma; BRCA=Breast invasive carcinoma; CESC=Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL=Cholangiocarcinoma; LCML=Chronic Myelogenous Leukemia; COAD=Colon adenocarcinoma; ESCA=Esophageal carcinoma; GBM=Glioblastoma multiforme; HNSC=Head and Neck squamous cell carcinoma; KICH=Kidney Chromophobe; KIRC=Kidney renal clear cell carcinoma; KIRP=Kidney renal papillary cell carcinoma; LIHC=Liver hepatocellular carcinoma; LUAD=Lung adenocarcinoma; LUSC=Lung squamous cell carcinoma; DLBC=Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; MESO=Mesothelioma; MISC=Miscellaneous; OV=Ovarian serous cystadenocarcinoma; PAAD=Pancreatic adenocarcinoma; PCPG=Pheochromocytoma and Paraganglioma; PRAD=Prostate adenocarcinoma; READ=Rectum adenocarcinoma; SARC=Sarcoma; SKCM=Skin Cutaneous Melanoma; STAD=Stomach adenocarcinoma; TGCT=Testicular Germ Cell Tumors; THYM=Thymoma; THCA=Thyroid carcinoma; UCS=Uterine Carcinosarcoma; UCEC=Uterine Corpus Endometrial Carcinoma; UVM=Uveal Melanoma.
