The short lifespan and systemic toxicity of IL-2 are major limitations for IL-2-based cancer immunotherapy. To overcome these hurdles, a single dose of a pressure-fused biomineral tablet is shown to safely support a two-phase IL-2 release, leading to weeks-long intratumoral retention of the cytokine to promote anti-tumor T cell immunity.
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Liu, J., Chen, X. Biomineral tablets for long-acting IL-2 immunotherapy. Nat Cancer (2025). https://doi.org/10.1038/s43018-025-00951-0
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DOI: https://doi.org/10.1038/s43018-025-00951-0
