Fig. 6: Antitumor and segmental bone defect healing ability of n-HA–loaded titanium scaffold.
From: Recent advances in drug delivery systems for osteosarcoma therapy and bone regeneration
a Diagram depicting the preparation of tumor cell suspension and seeding into scaffold. b Implantation of tumor cell–seeded scaffold at segmental bone defect of rabbit femur. c Tumor volume of the rabbits implanted with empty scaffolds or n-HA/scaffolds within 5 weeks. Error bars represent SD. n = 4 per group. **P < 0.01 compared to empty scaffold, two-way t test. d Photographs of excised implants with tumor from weeks 2 to 5. e Micro-CT–reconstructed images of the implants and adjacent bone tissue. B, bone; S, scaffold; arrows show adjacent cortical bone resorption by tumor. f Histological observation of the implanted scaffolds. S, scaffold; T, tumor; red arrows indicate new bone formation. (Adapted with permission from ref. 115).
