Extended Data Fig. 3: Mitochondrial activation in DAM.
From: Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
a, GSEA of APP751SL/+ (left) or MAPTp301S/+ ES DAM (middle and right) versus (vs) wild-type (WT) 12mo microglia. Enrichment plots and heat maps (middle) of top 30 ranking leading edge genes of the oxidative phosphorylation (OXPHOS) GS. Red symbolizes overexpression and blue down regulation (see Supplementary Data Table for shade values). b, Sector graphs of the most enriched biological functions between the 15 top GSs enriched in APP751SL/+ and MAPTp.P301S/+ DAM vs WT microglia. c, GSEA of 5xfAD/+; SOD1p.G93A/+, and aged (24mo) DAM vs WT age matched or young (5mo) microglia. Enrichment plots and heat maps of up to the top 30 ranking leading edge genes of OXPHOS GS. d, GSEA of APP751SL/+ DAM vs wild-type (WT) 12mo microglia. Enrichment plot of the oxidative phosphorylation (OXPHOS) GS.
