Extended Data Fig. 9: Analyses of overlapping enriched ontological pathways among bumetanide-treated apoE4-KI mice, J20/E4-KI mice, human iPSC-derived neurons, and human apoE4/4-specific transcriptomic signature of AD. | Nature Aging

Extended Data Fig. 9: Analyses of overlapping enriched ontological pathways among bumetanide-treated apoE4-KI mice, J20/E4-KI mice, human iPSC-derived neurons, and human apoE4/4-specific transcriptomic signature of AD.

From: Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease

Extended Data Fig. 9

a, 22 overlapping enriched ontological pathways (Supplementary Table 17) in bumetanide-flipped cell clusters in apoE4-KI mice vs J20/E4-KI mice. b, Six overlapping enriched ontological pathways (Supplementary Table 18) in bumetanide-flipped cell clusters in apoE4-KI mice vs J20/E4-KI mice vs E4/4-hiPSC neurons. c, Three overlapping enriched ontological pathways in bumetanide-flipped cell clusters in apoE4-KI mice vs J20/E4-KI mice vs E4/4-hiPSC neurons vs human E4/4 signature of AD, which include GABAergic Synapse, Circadian Entrainment, Morphine Addiction pathways.

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