Extended Data Fig. 2: Monocyte-derived macrophages do not contribute to the pool of activated microglia in Trem2+/+5xFAD mice. | Nature Aging

Extended Data Fig. 2: Monocyte-derived macrophages do not contribute to the pool of activated microglia in Trem2+/+5xFAD mice.

From: Alzheimer’s disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis

Extended Data Fig. 2

(a) FACS gating strategy for isolating all leukocytes (CD45+) and bone marrow (BM)-derived leukocytes (CD45+GFP+) from whole brains of GFP-BM transplanted Trem2+/+5xFAD mice. (b) Cumulative bar graph showing the percentage of each cell population out of all the cells collected using the CD45+ gate or the CD45+GFP+ gate. (c) Cumulative bar graphs of individual animals showing the percentage of each cell population out of all the cells collected using the CD45 + gate or CD45 + GFP + gate in IgG2b or anti-PD-L1 treated animals, corresponding to Fig. 1f,g; also shown are additional 2 WT samples.

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