Extended Data Fig. 10: In MA10-infected Balb/c mice, senescence-like phenotypes appeared in inverse proportion to the decrease in the virus. | Nature Aging

Extended Data Fig. 10: In MA10-infected Balb/c mice, senescence-like phenotypes appeared in inverse proportion to the decrease in the virus.

From: SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Extended Data Fig. 10

a,b, Balb/c mice were intranasally inoculated with MA10, 1.0 × 104 TCID50 (in 50 μL). The body weight was monitored until day 14 (n = 3) (a). MA10 infected balb/c mice were euthanized on day 4 (n = 3) and day 14 (n = 3) post-infection, and RT-qPCR analysis was performed to examine the indicated gene expression. The data for mock and SARS-CoV-2-infected hamsters are the same as those used in Fig. 4a–e. For all graphs, error bars indicate mean ± standard deviation (s.d.). Statistical significance was determined with one-way ANOVA followed by Dunnett’s multiple comparison test in (b).

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