Extended Data Fig. 6: Rapamycin treatment increases expression of histone H3, histone H4 and Bchs in intestines of females but not in males.

a, The expression of histones H3 and H4 in intestines of wDah females was lower than in males, and rapamycin treatment (200 µM) increased it, at 10 days of age (n = 4 biological replicates of 10 intestines per replicate, two-way ANOVA, H3, interaction p < 0.05, H4, interaction p < 0.001; post-hoc test). b, The expression of Bchs in intestines of wDah females was lower than in males, and rapamycin treatment (200 µM) increased it, at 10 days of age (n = 4 biological replicates of 10 intestines per replicate, two-way ANOVA, interaction p > 0.05; post-hoc test). Data are presented as mean values ± s.e.m.