Fig. 4: Bchs is a required target for autophagy activation, lifespan extension and intestinal homeostasis from the mTORC1–histone axis. | Nature Aging

Fig. 4: Bchs is a required target for autophagy activation, lifespan extension and intestinal homeostasis from the mTORC1–histone axis.

From: Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

Fig. 4

a, Knockdown of Bchs in ECs of adult females had no effect on lifespan, but it abolished the increase in lifespan in response to rapamycin (long-rank test, control versus RU486 P = 0.40, rapamycin versus rapamycin+RU486 P = 0.0065, n = 198–199 flies per condition). b, Knockdown of Bchs in ECs of adult males shortened lifespan (long-rank test, control versus RU486 P = 0.0095, n = 198-200 flies per condition). c, Knockdown of Bchs in ECs of adult females had no effect on lifespan but abolished the increase in lifespan in response to spermidine (long-rank test, control versus RU486 P = 0.54, spermidine versus spermidine + RU486 P = 0.012, n = 198–199 flies per condition). d, Knockdown of Bchs in enterocytes of adult males shortened lifespan (long-rank test, control versus RU486 P = 0.023, n = 199 flies per condition). See also Supplementary Tables 5 and 6.

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