Extended Data Fig. 10: Comparison of CD4 and CD8 TCR repertoires between young and old donors before and after vaccination. | Nature Aging

Extended Data Fig. 10: Comparison of CD4 and CD8 TCR repertoires between young and old donors before and after vaccination.

From: Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Extended Data Fig. 10

(a) Diversity estimation of CD4 TCR repertoire in young (n = 3) and old (n = 3) donors before and after vaccination (7 days after the second dose). Higher value for greater diversity. *: p < 0.05; **: p < 0.01; ***: p < 0.001; ns: not significant. Wilcoxon Rank Sum test (two-sided). (b) Clonotype expansion of the top 40 CDR3 clonotypes for CD8 TCRα, CD4 TCRα, CD4 TCRβ for young and old groups before and after vaccination (7 days after the second dose).

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