Extended Data Fig. 9: Overexpression of Altre rescues the decreased MMP in Treg cells isolated from aged Altre cKO mice.
From: A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
a, Representative flow cytometry plots of aged Altre-KO Tregs (n = 6), aged Altre-KO Tregs infected with NC (n = 3) and mouse Altre-overexpression lentivirus vectors (n = 3), and then performed mitochondrial membrane potential (MMP) analysis by using the cationic fluorescent dye JC-10. Treg cells were isolated from Altre-KO mice (14 months old). b, Statistical analysis of mean fluorescence intensity (MFI) of JC-10 in aged Altre-KO Tregs, aged Altre-KO Tregs infected with negative control (NC) and Altre-overexpression lentivirus vectors as in a. Two-tailed t-test. Data are mean ± s.d.
