Extended Data Fig. 8: Dissecting the SIRT2-STAT3-CDKN2B axis in human cardiomyocytes.
From: SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B
a,b, Western blotting of CDKN2B in male hESC-derived (a) or hiPSC-derived (b) cardiomyocytes transduced with lentiviral shSIRT2 or shGL2. c, Western blotting of CDKN2B in wildtype human cardiomyocytes transduced with lentiviruses expressing Luc, STAT3-WT, or STAT3-K685R. Two-tailed Student’s t-test was used for statistical analysis in a-c. Data are presented as the mean ± s.e.m. n = 4, 3, 3 independent experiments in a, b, c, respectively. For western blotting, GAPDH was used as the control. hCardiomyocyte, human cardiomyocyte.
