Extended Data Fig. 4: Plasma p-tau217⁺ change according to longitudinal tau accumulation status.

Violin plot of plasma p-tau217⁺ change across groups defined based on longitudinal tau accumulation status. The horizontal line inside each box depicts the median, and box ends represent the 25th and 75th percentiles, with whiskers extending to 1.5 × interquartile range. Groups were compared using two-sided analysis of covariance. The P value was computed from a model adjusted for age, sex, diagnosis, and baseline plasma p-tau217⁺ levels. Analyses were conducted on a subset of 65 individuals (Supplementary Table 4). Abbreviation: p-tau217⁺ = phosphorylated tau at threonine 217.