Extended Data Fig. 7: Similar fasting total cholesterol level in young Cd8-/- mice adoptively transferred with 10 million CD8+ T cells or vehicle from either young C57BL/6 WT or aged C57BL/6 WT mice over 10-weeks of WD feeding. | Nature Aging

Extended Data Fig. 7: Similar fasting total cholesterol level in young Cd8-/- mice adoptively transferred with 10 million CD8+ T cells or vehicle from either young C57BL/6 WT or aged C57BL/6 WT mice over 10-weeks of WD feeding.

From: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice

Extended Data Fig. 7

All mice were adoptively transferred and allowed to rest for 4-weeks before PCSK9-AAV injection and 10-week WD feeding. Fasting total cholesterol was quantified from plasma via colorimetric assay. 2-way ANOVA with Tukey’s post-hoc test. N = 13 young Cd8-/- mice + young CD8+ T cells, N = 8 young Cd8-/- mice + aged CD8+ T cells, and N = 7 young Cd8-/- mice + no CD8+ T cells over 2 independent experiments. Data in this figure represents mean ± SEM. Measurements were taken from distinct samples. WD = western diet, WT = wild-type.

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