Extended Data Fig. 9: Atherosclerotic plaque T cells are more clonally expanded than splenic T cells and aging enhances clonal expansion. | Nature Aging

Extended Data Fig. 9: Atherosclerotic plaque T cells are more clonally expanded than splenic T cells and aging enhances clonal expansion.

From: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice

Extended Data Fig. 9

(a) Abundance of unique clonotypes. (b) Clonotype diversity estimation by Chao1 index. (c) Length of CDR3 sequences by group. (d) Size of clonotypes by group. (e) Clonotype tracking of the top 5 clonotypes from each sample across all other samples. (f) Overlap of CDR3 sequences by sample in circos plot. Top 100 expanded CDR3 sequences, colored by group, of 15 amino acids (g), 10 amino acids (h), and 5 amino acids (i). Composition of amino acid sequences of different lengths including 15 amino acids (j), 10 amino acids (k), and 5 amino acids (l). Depiction of which samples had the greatest clonal expansion shared across the number of cells (x-axis) and number of samples (y-axis) and stratified by group (m), age (n), and tissue-type (o). Data includes young spleens (N = 3 biological replicates and 18,412 total cells), aged spleen (N = 3 biological replicates and 11,151 total cells), young aorta (N = 4 biological replicates and 1,999 total cells), and aged aorta (N = 4 biological replicates and 5,698 total cells) over 1 independent experiment.

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