Extended Data Fig. 3: GSEA enrichment analysis for the pathways related to ovarian function and mitochondrial functions.

a. GSEA analysis showing that the pathways of ovulation cycles, female gamete generation, reproductive system development, embryonic morphogenesis, embryonic organ development, and mitotic cell cycle were enriched in 8-month-old Cd38−/− compared to age-matched WT mice. b. GSEA analysis showed the pathways of female gamete generation, mitochondrial matrix, mitochondrial transport, ovulation cycle process, oogenesis, and ovarian follicle development in 12-month-old Cd38−/− compared to age-matched WT mice. P values were calculated based on Fisher′s Exact Test.