Extended Data Fig. 5: atg-16.2 and atg-4.1 mutants display similar RNAi phenotypes. | Nature Aging

Extended Data Fig. 5: atg-16.2 and atg-4.1 mutants display similar RNAi phenotypes.

From: Autophagy protein ATG-16.2 and its WD40 ___domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons

Extended Data Fig. 5

(a-d) Phenotypes of day 2 WT, atg-16.2(ok3224), atg-4.1(bp501), and sid-1(qt9) animals after whole-life RNAi against a specific gene expressed in different tissues. Mean percent phenotypic penetrance after knockdown of genes with functions in (a) body-wall muscle; unc-22 – twitching and uncoordinated movement (Unc) and unc-112 – paralysis, (b) a ubiquitous manner; rpl-2 – larval arrest, (c) hypodermis; tsp-15 – blisters and bli-1 – blisters and larval arrest; (d) intestine; elt-2 – clear and larval arrest. Error bars are s.d. of n = 4 experiments. (a) unc-22 RNAi: ns P = 0.59, P = 0.87, ****P < 0.0001. unc-112 RNAi: ns P = 0.92, P = 0.96, ****P < 0.0001. (b) rpl-2 RNAi: ns P = 0.82, P = 0.96, ****P < 0.0001. (c) tsp-15 RNAi: ns P = 0.99, P = 0.64, ****P < 0.0001. bli-1 RNAi: ns P = 0.24, P = 0.99, ****P < 0.0001. (d) elt-2 RNAi: ns P = 0.76, P = 0.18, ****P < 0.0001 by one-way one-way ANOVA with Dunnett’s multiple comparisons test.

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