Fig. 2: DNA methylation profiles of replicative senescence-associated genes.
From: Conserved epigenetic hallmarks of T cell aging during immunity and malignancy
a, Representative CpG DNA methylation plot of Cdkn2a/2b loci in naive, young memory and ML memory CD8+ T cells. b, Summary graph of total DMR methylation among the Cdkn2a/b loci for young and ML memory CD8+ T cells. n = 2–5 for biologically independent samples. The P value based on a two-sided Student’s t-test. The box and hinges correspond to the first, second and third quartiles, the upper whisker extends to the minimum (largest value, upper hinge + 1.5 × interquartile range) and the lower whisker extends to the maximum (smallest value, lower hinge − 1.5 × interquartile range). c, Representative CpG DNA methylation of Mdm2, Rb1 and Cdk6. d, Venn diagram showing overlap between OIS-activated enhancers and top 139 DMRs.
