Extended Data Fig. 2: Haenkenium protects joints and modulates cytokine expression in tissues.
a, Representative micrographs of Hematoxylin & Eosin staining of the knee joints of young (4-month-old), 24-month-old untreated, and 24-month-old treated animals after 4 months of treatment (top images observed at 10x magnification, bottom at 40x). Scalebar = 200 μm, inserts 50 μm. Photomicrographs representative of similar results from Young n = 8; UT n = 10; T n = 12 independent experiments. b, Proteome profiler analysis of cytokines expressed in serum of 24-month old untreated and animals, after 4 months of treatment. The heatmap represents the log2 fold change of the comparison between treated and untreated animals. c, Proteome profiler analysis of cytokines of kidney protein lysates from young (4-month-old), 24-month-old untreated, and 24-month-old treated mice after 4 months of treatment. The heatmap represents the fold change (FC) of the comparison of untreated/treated old mice relative to young. d, Highlight of proteins that are increased (FC > 1.5) and decreased (FC < 0.75) by aging, respectively.
